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The current evidence base — primarily from animal studies and limited human trials — suggests the following potential applications: Improved sleep quality — increased proportion of slow-wave sleep, reduced sleep latency, fewer nocturnal cortisol spikes Cortisol normalisation — reduced HPA hyperactivation, particularly relevant in high-stress or metabolically burdened patients Nociceptive effects — several studies indicate DSIP modulates pain processing, with implications for patients whose poor sleep is pain-driven (3) Antioxidant activity — may reduce oxidative stress markers, which are elevated in both sleep-deprived and insulin-resistant individuals Neuroendocrine support — preliminary evidence of effects on LH, FSH, and somatostatin — hormones that regulate testosterone, oestrogen, and growth hormone release Potential stress adaptation — some data suggest DSIP may reduce the physiological stress response magnitude without blunting alertness It is important to be precise here
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One animal study found signs of ovarian tissue changes when high doses were administered intramuscularly
